Article
An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells.
Autophagy - 2 Sept 2017
Martin Shaun, Dudek-Peric Aleksandra M, Garg Abhishek D, Roose Heleen, Demirsoy Seyma, Van Eygen Sofie, Mertens Freya, Vangheluwe Peter, Vankelecom Hugo, Agostinis Patrizia
Abstract excerpt
The ingrained capacity of melanoma cells to rapidly evolve toward an aggressive phenotype is manifested by their increased ability to develop drug-resistance, evident in the case of vemurafenib, a therapeutic-agent targeting BRAFV600E. Previous studies indicated a tight correlation between heightened melanoma-associated macroautophagy/autophagy and acquired Vemurafenib resistance. However, how this vesicular...
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