Article
Loss of Ambra1 promotes melanoma growth and invasion.
Nature communications - 5 May 2021
Di Leo Luca, Bodemeyer Valérie, Bosisio Francesca M, Claps Giuseppina, Carretta Marco, Rizza Salvatore, Faienza Fiorella, Frias Alex, Khan Shawez, Bordi Matteo, Pacheco Maria P, Di Martino Julie, Bravo-Cordero Jose J, Daniel Colin J, Sears Rosalie C, Donia Marco, Madsen Daniel H, Guldberg Per, Filomeni Giuseppe, Sauter Thomas, Robert Caroline, De Zio Daniela, Cecconi Francesco
Abstract excerpt
Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the molecular mechanisms underlying melanoma biology and in defining new curative strategies, the therapeutic needs for this disease have not yet been fulfilled. Herein, we provide evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributes to melanoma development. Indeed, we show that Ambra1...
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