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Article

The role of lipid signaling in the progression of malignant melanoma.

Cancer metastasis reviews - 1 Sept 2018

Tímár József, Hegedüs B, Rásó E

Abstract excerpt

In the past decades, a vast amount of data accumulated on the role of lipid signaling pathways in the progression of malignant melanoma, the most metastatic/aggressive human cancer type. Genomic studies identified that PTEN loss is the leading factor behind the activation of the PI3K-signaling pathway in melanoma, mutations of which are one of the main resistance mechanisms behind target therapy failures. On the...

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Identifiers

PMID: 29808460
DOI: 10.1007/s10555-018-9729-x

Genes

NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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