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Article

Development of Small Molecule MEIS Inhibitors that modulate HSC activity

14 May 2020

Abstract excerpt

Abstract Meis1 , which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors of MEIS1 remained unknown. This led us to develop inhibitors of MEIS1 that could modulate HSC activity. To this end, we have established a library of relevant homeobox family...

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PMID: 32409701
DOI: 10.1038/s41598-020-64888-3

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