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Article

MEIS1 regulates early erythroid and megakaryocytic cell fate

8 Aug 2014

Abstract excerpt

MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests that the function of MEIS1 in stem cells is distinct from its function in lineage committed cells. Mouse models show that Meis1 is required for renewal of stem cells, but the function of MEIS1 in human hematopoietic progenitor cells has not been...

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PMID: 25107888
DOI: 10.3324/haematol.2014.106567

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