Article
Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness.
Cancer research - 2 Dec 2022
Liu Alex C H, Cathelin Severine, Yang Yitong, Dai David L, Ayyathan Dhanoop Manikoth, Hosseini Mohsen, Minden Mark D, Tierens Anne, Chan Steven M
Abstract excerpt
Mutant isocitrate dehydrogenase 1 (IDH1) and IDH2 block the differentiation of acute myeloid leukemia (AML) cells through production of R-2-hydroxyglutarate (R-2-HG). IDH inhibitors can induce differentiation of AML cells by lowering R-2-HG but have limited clinical efficacy as single agents. Here, we performed a genome-wide CRISPR knockout screen in an Idh1-mutated hematopoietic progenitor cell line to identify...
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