Article

Development of Small Molecule MEIS Inhibitors that modulate HSC activity

2020-02-13

Abstract excerpt

Meis1 , which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors of MEIS1 remained unknown. This led us to develop inhibitors of MEIS1 that could modulate HSC activity. To this end, we have established a library of relevant homeobox family inhibitors and deve...

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Literature Corpus work: 89826552-9317-57c0-97ce-ca6c7a7c1c98
DOI: 10.1101/2020.02.12.946491

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