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Article

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.

Cell death & disease - 14 May 2020

Sanna Simona, Esposito Sonia, Masala Alessandra, Sini Paola, Nieddu Gabriele, Galioto Manuela, Fais Milena, Iaccarino Ciro, Cestra Gianluca, Crosio Claudia

Abstract excerpt

TDP-43 pathology is a disease hallmark that characterizes both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). TDP-43 undergoes several posttranslational modifications that can change its biological activities and its aggregative propensity, which is a common hallmark of different neurodegenerative conditions. New evidence is provided by the current study pointing at TDP-43...

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Identifiers

PMID: 32409664
DOI: 10.1038/s41419-020-2580-3
PMCID: PMC7224392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.PMID 32409664Read ↗

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