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Article

TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

10 Aug 2015

Abstract excerpt

In recent times, high-throughput screening analyses have broadly defined the RNA cellular targets of TDP-43, a nuclear factor involved in neurodegeneration. A common outcome of all these studies is that changing the expression levels of this protein can alter the expression of several hundred RNAs within cells. What still remains to be clarified is which changes represent direct cellular targets of TDP-43 or just...

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PMID: 26261209
DOI: 10.1093/nar/gkv814

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