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Article

Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Xia Qin, Wang Hongfeng, Zhang Yan, Ying Zheng, Wang Guanghui

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset, and progressive neurodegenerative disorder with no cure. Cu/Zn-superoxide dismutase (SOD1) was the first identified protein associated with familial ALS; and aggresome formation of misfolded SOD1 is closely associated with ALS pathogenesis. HDAC6, one of the histone deacetylase family members, has already been demonstrated to play an important role in...

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Source

Identifiers

PMID: 25720411
DOI: 10.3233/JAD-142244

Genes

SOD1
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner.PMID 25720411Read ↗

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6Semantic proximity Read ↗

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target CellsSemantic proximity Read ↗

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.Semantic proximity Read ↗

HDAC6 and TDP-43 promote autophagy impairment in amyotrophic lateral sclerosisSemantic proximity Read ↗

Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.Semantic proximity Read ↗

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.Semantic proximity Read ↗

Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila.Semantic proximity Read ↗

TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.Semantic proximity Read ↗

Interplay Between HDAC6 and Its Interacting Partners: Essential Roles in the Aggresome-Autophagy Pathway and Neurodegenerative DiseasesSemantic proximity Read ↗

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.Semantic proximity Read ↗

Aggresome Formation and Liquid-liquid Phase Separation Independently Induce Cytoplasmic Aggregation of TAR DNA-binding protein 43Semantic proximity Read ↗

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43Semantic proximity Read ↗

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