Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.

Nature communications - 20 Dec 2025

Jun Yong-Woo, Lee Soojin, Almeida Sandra, Freude Kristine K, Ichida Justin K, Gao Fen-Biao

Abstract excerpt

Although TDP-43 pathology is found in most sporadic and familial ALS and FTD cases, other shared pathogenic mechanisms remain largely unknown. Here we show that SIRT1 levels are decreased and acetylated p53 levels are increased in iPSC-derived neurons from sALS patients and with the FTD3-causing CHMP2B mutation. Ectopic expression of SIRT1 in these patient neurons rescues neurodegeneration and reduces acetylated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Drosophila

Share to Frontotemporal Dementia

Share to Induced Pluripotent Stem Cells

Share to Ku Autoantigen

Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 41422089
DOI: 10.1038/s41467-025-67749-7
PMCID: PMC12847843

Genes

SIRT1
CHMP2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.PMID 41422089Read ↗

Genome instability underlies an augmented DNA damage response in familial and sporadic ALS human iPSC-derived motor neuronsSemantic proximity Read ↗

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.Semantic proximity Read ↗

Sirtuins: Common Targets in Aging and in NeurodegenerationSemantic proximity Read ↗

Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s diseaseSemantic proximity Read ↗

SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's diseaseSemantic proximity Read ↗

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic ImplicationSemantic proximity Read ↗

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.Semantic proximity Read ↗

Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal CellsSemantic proximity Read ↗

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disordersSemantic proximity Read ↗

HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models.Semantic proximity Read ↗

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell deathSemantic proximity Read ↗

DNA Damage and Chromatin Rearrangement Work Together to Promote NeurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.