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HDAC6 and TDP-43 promote autophagy impairment in amyotrophic lateral sclerosis

3 Sept 2025

Abstract excerpt

TDP-43 is known to bind the mRNA of histone deacetylase 6 (HDAC6), influencing its RNA translation. Many studies suggest that HDAC6 participates in the regulation of autophagy, which we found impaired in sporadic amyotrophic lateral sclerosis (sALS) patients. Aim of this work is to evaluate the interaction between TDP-43 and HDAC6 mRNA and to evaluate the effect of the up- and down-regulation of HDAC6 on...

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PMID: 40912409
DOI: 10.1016/j.nbd.2025.107079

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