Article
A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry.
European urology - 1 Sept 2020
Darst Burcu F, Wan Peggy, Sheng Xin, Bensen Jeannette T, Ingles Sue A, Rybicki Benjamin A, Nemesure Barbara, John Esther M, Fowke Jay H, Stevens Victoria L, Berndt Sonja I, Huff Chad D, Strom Sara S, Park Jong Y, Zheng Wei, Ostrander Elaine A, Walsh Patrick C, Srivastava Shiv, Carpten John, Sellers Thomas A, Yamoah Kosj, Murphy Adam B, Sanderson Maureen, Crawford Dana C, Gapstur Susan M, Bush William S, Aldrich Melinda C, Cussenot Olivier, Yeager Meredith, Petrovics Gyorgy, Cullen Jennifer, Neslund-Dudas Christine, Kittles Rick A, Xu Jianfeng, Stern Mariana C, Kote-Jarai Zsofia, Govindasami Koveela, Chokkalingam Anand P, Multigner Luc, Parent Marie-Elise, Menegaux Florence, Cancel-Tassin Geraldine, Kibel Adam S, Klein Eric A, Goodman Phyllis J, Drake Bettina F, Hu Jennifer J, Clark Peter E, Blanchet Pascal, Casey Graham, Hennis Anselm J M, Lubwama Alexander, Thompson Ian M, Leach Robin, Gundell Susan M, Pooler Loreall, Xia Lucy, Mohler James L, Fontham Elizabeth T H, Smith Gary J, Taylor Jack A, Eeles Rosalind A, Brureau Laurent, Chanock Stephen J, Watya Stephen, Stanford Janet L, Mandal Diptasri, Isaacs William B, Cooney Kathleen, Blot William J, Conti David V, Haiman Christopher A
Abstract excerpt
Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry-specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We...
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