Article
A west African ancestry-associated SNP on 8q24 predicts a positive biopsy in African American men with suspected prostate cancer following PSA screening.
The Prostate - 1 May 2024
Gu Jian, Chery Lisly, González Graciela M Nogueras, Huff Chad, Strom Sara, Jones Jeffrey A, Griffith Donald P, Canfield Steven E, Wang Xuemei, Huang Xuelin, Roberson Pamela, Meng Qing H, Troncoso Patricia, Ittmann Michael, Covinsky Michael, Scheurer Michael, Irizarry Ramirez Margarita, Pettaway Curtis A
Abstract excerpt
BACKGROUND: African American (AA) men have the highest incidence and mortality rates of prostate cancer (PCa) among all racial groups in the United States. While race is a social construct, for AA men, this overlaps with west African ancestry. Many of the PCa susceptibility variants exhibit distinct allele frequencies and risk estimates across different races and contribute substantially to the large disparities...
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