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Article

MAPT haplotype-stratified GWAS reveals differential association for AD risk variants.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2020

Strickland Samantha L, Reddy Joseph S, Allen Mariet, N'songo Aurelie, Burgess Jeremy D, Corda Morgane M, Ballard Travis, Wang Xue, Carrasquillo Minerva M, Biernacka Joanna M, Jenkins Gregory D, Mukherjee Shubhabrata, Boehme Kevin, Crane Paul, Kauwe John S, Ertekin-Taner Nilüfer

Abstract excerpt

INTRODUCTION: MAPT H1 haplotype is implicated as a risk factor for neurodegenerative diseases including Alzheimer's disease (AD). METHODS: Using Alzheimer's Disease Genetics Consortium (ADGC) genome-wide association study (GWAS) data (n = 18,841), we conducted a MAPT H1/H2 haplotype-stratified association to discover MAPT haplotype-specific AD risk loci. RESULTS: We identified 11 loci-5 in H2-non-carriers and 6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32400971
DOI: 10.1002/alz.12099
PMCID: PMC7983911

Genes

MAPT
GABRG2
NECTIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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