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Article

MAPT Locus in Parkinson's Disease Patients of Ashkenazi Origin: A Stratified Analysis.

Genes - 28 Dec 2023

Shani Shachar, Gana-Weisz Mali, Bar-Shira Anat, Thaler Avner, Gurevich Tanya, Mirelman Anat, Giladi Nir, Alcalay Roy N, Goldstein Orly, Orr-Urtreger Avi

Abstract excerpt

Introduction: MAPT locus is associated with Parkinson's disease (PD), which is located within a large inversion region of high linkage disequilibrium (LD). We aimed to determine whether the H2-haplotype protective effect and its effect size depends on the GBA1 or LRRK2 risk allele carrier status, and to further characterize genetic alterations that might contribute to its effect. Methods: LD analysis was...

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Identifiers

PMID: 38254936
DOI: 10.3390/genes15010046
PMCID: PMC10815687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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