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Article

Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana.

The Journal of infectious diseases - 1 May 2016

Chenet Stella M, Akinyi Okoth Sheila, Huber Curtis S, Chandrabose Javin, Lucchi Naomi W, Talundzic Eldin, Krishnalall Karanchand, Ceron Nicolas, Musset Lise, Macedo de Oliveira Alexandre, Venkatesan Meera, Rahman Reyaud, Barnwell John W, Udhayakumar Venkatachalam

Abstract excerpt

Suspected artemisinin resistance in Plasmodium falciparum can be explored by examining polymorphisms in the Kelch (PfK13) propeller domain. Sequencing of PfK13 and other gene resistance markers was performed on 98 samples from Guyana. Five of these samples carried the C580Y allele in the PfK13 propeller domain, with flanking microsatellite profiles different from those observed in Southeast Asia. These molecular...

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PMID: 26690347
DOI: 10.1093/infdis/jiv752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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