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Article

Kelch13 mutations in Plasmodium falciparum and risk of spreading in Amazon basin countries.

The Journal of antimicrobial chemotherapy - 11 Oct 2021

Mathieu Luana C, Singh Prabhjot, Monteiro Wuelton Marcelo, Magris Magda, Cox Horace, Lazrek Yassamine, Melo Gisely C, Marchesini Paola, Alexandre Jean S F, Alvarez Angel Manuel, Demar Magalie, Douine Maylis, Ade Maria-Paz, Lacerda Marcus V G, Musset Lise

Abstract excerpt

BACKGROUND: The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana. OBJECTIVES: This study aimed to strengthen pfk13 monitoring in the Amazon basin countries, to compile the available data and to evaluate the risk of spreading of mutations. METHODS: Sanger sequencing was done...

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Identifiers

PMID: 34379746
DOI: 10.1093/jac/dkab264
PMCID: PMC8521405

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