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Article

Bax inhibitor-1 deficiency leads to obesity by increasing Ca2+-dependent insulin secretion.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2020

Philippaert Koenraad, Roden Michael, Lisak Dmitrij, Bueno Diones, Jelenik Tomas, Radyushkin Konstantin, Schacht Teresa, Mesuere Margot, Wüllner Verena, Herrmann Ann-Kathrin, Baumgart Jan, Vennekens Rudi, Methner Axel

Abstract excerpt

Transmembrane BAX inhibitor motif containing 6 (TMBIM6), also known as Bax inhibitor-1, is an evolutionarily conserved protein involved in endoplasmic reticulum (ER) function. TMBIM6 is an ER Ca2+ leak channel and its deficiency enhances susceptibility to ER stress due to inhibition of the ER stress sensor IRE1α. It was previously shown that TMBIM6 overexpression improves glucose metabolism and that TMBIM6...

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Identifiers

PMID: 32394396
DOI: 10.1007/s00109-020-01914-x
PMCID: PMC7297831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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