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Article

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders.

Current molecular medicine - 1 Jan 2015

Gao R, Penzes P

Abstract excerpt

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with complex genetic architectures but overlapping behavioral phenotypes, which suggests common pathway perturbations. Multiple lines of evidence implicate imbalances in excitatory and inhibitory activity (E/I imbalance) as a shared pathophysiological mechanism. Thus, understanding the molecular underpinnings of E/I imbalance may...

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Identifiers

PMID: 25732149
DOI: 10.2174/1566524015666150303003028
PMCID: PMC4721588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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