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Article

Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.

Blood - 3 Sept 2020

Tulstrup Morten, Moriyama Takaya, Jiang Chuang, Grosjean Marie, Nersting Jacob, Abrahamsson Jonas, Grell Kathrine, Hjalgrim Lisa Lyngsie, Jónsson Ólafur Gísli, Kanerva Jukka, Lund Bendik, Nielsen Stine Nygaard, Nielsen Rikke Linnemann, Overgaard Ulrik, Quist-Paulsen Petter, Pruunsild Kaie, Vaitkeviciene Goda, Wolthers Benjamin Ole, Zhang Hui, Gupta Ramneek, Yang Jun J, Schmiegelow Kjeld

Abstract excerpt

Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we performed a genome-wide association study in 447 ALL cases from the Nordic Society for Pediatric Haematology and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32391884
DOI: 10.1182/blood.2020005064
PMCID: PMC7472715

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