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The impact of genetic variations in FPGS , MTHFR , and ATIC on methotrexate response among pediatric patients with acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Jun 2025

Wang Shu-Mei, Zhao Dan-Qi, Kong Xiao-Yan, Li Miao

Abstract excerpt

OBJECTIVES: Genetic polymorphisms in FPGS , MTHFR , and ATIC have emerged as important modulators of methotrexate (MTX) metabolism and toxicity. We investigated the distribution of FPGS rs10106, MTHFR rs1801131, and ATIC rs2372536 polymorphisms in children with acute lymphoblastic leukemia (ALL) and assessed their influence on MTX concentrations, toxicity profiles, and clinical outcomes. METHODS: Genotyping of...

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Share to Antimetabolites, Antineoplastic
Share to Hydroxymethyl and Formyl Transferases
Share to Infant
Share to Methotrexate
Share to Methylenetetrahydrofolate Reductase (NADPH2)
Share to Multienzyme Complexes
Share to Peptide Synthases
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 39991907
DOI: 10.1097/FPC.0000000000000563

Genes

ATIC
FPGS
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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