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Article

A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation.

Molecular biomedicine - 21 Nov 2025

Yu Wenliang, Li Chenyang, Meng Yuning, Li Qiang, Gao Mengyue, Tang Wei, Li Yao, Tan Ziyi, Zhou Xiaoran, Liu Zeyang, Xu Yun, Hua Zichun

Abstract excerpt

For over 70 years, methotrexate (MTX) has remained a first-line chemotherapeutic agent for acute lymphoblastic leukemia (ALL), playing a pivotal role in maintenance therapy. Understanding the genetic determinants of MTX efficacy is therefore essential for improving clinical outcomes. However, studies on MTX efficacy-related polymorphisms remain limited, particularly for non-coding variants, for which most...

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Identifiers

PMID: 41269429
DOI: 10.1186/s43556-025-00353-9
PMCID: PMC12638486

Genes

FPGS

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A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation.PMID 41269429Read ↗

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