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Article

Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.

Blood - 7 May 2009

French Deborah, Yang Wenjian, Cheng Cheng, Raimondi Susana C, Mullighan Charles G, Downing James R, Evans William E, Pui Ching-Hon, Relling Mary V

Abstract excerpt

Methotrexate polyglutamates (MTXPGs) determine in vivo efficacy in acute lymphoblastic leukemia (ALL). MTXPG accumulation differs by leukemic subtypes, but genomic determinants of MTXPG variation in ALL remain unclear. We analyzed 3 types of whole genome variation: leukemia cell gene expression and somatic copy number variation, and inherited single nucleotide polymorphism (SNP) genotypes and determined their...

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Source

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Identifiers

PMID: 19066393
DOI: 10.1182/blood-2008-07-172106
PMCID: PMC2680361

Genes

FHOD3
IMPA2
RASSF4
SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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