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Article

Genetic factors involved in delayed methotrexate elimination in children with acute lymphoblastic leukemia.

Pediatric blood & cancer - 1 May 2021

Cheng Yu, Chen Mao-Hua, Zhuang Qian, Lin Bi-Juan, Chen Ying-Ying, Yang Ling, Liu Mao-Bai, Que Wan-Cai, Qiu Hong-Qiang

Abstract excerpt

BACKGROUND: Delayed excretion of methotrexate can lead to life-threatening toxicity that may result in treatment cessation, irreversible organ damage, and death. Various factors have been demonstrated to influence the pharmacokinetic process of methotrexate, including genetic and nongenetic factors. METHODS: We investigated the genetic factors primarily related to the metabolic pathway of methotrexate in children...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33501733
DOI: 10.1002/pbc.28858

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