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Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo

8 Nov 2020

Abstract excerpt

BACKGROUNDInterpatient differences in the accumulation of methotrexate's active polyglutamylated metabolites (MTXPGs) in leukemia cells influence its antileukemic effects.METHODSTo identify genomic and epigenomic and patient variables determining the intracellular accumulation of MTXPGs, we measured intracellular MTXPG levels in acute lymphoblastic leukemia (ALL) cells from 388 newly diagnosed patients after in...

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PMID: 33164984
DOI: 10.1172/jci140797

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