Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues.

eLife - 9 Jul 2013

Nowak Katarzyna, Seisenbacher Gerhard, Hafen Ernst, Stocker Hugo

Abstract excerpt

How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under var...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Transport Systems
Share to Caloric Restriction
Share to Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Phosphatidylinositol Phosphates

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 23853709
DOI: 10.7554/eLife.00380
PMCID: PMC3707060

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23853709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues.PMID 23853709Read ↗

FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction.Semantic proximity Read ↗

Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.Semantic proximity Read ↗

Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.Semantic proximity Read ↗

Genes affecting cell competition in Drosophila.Semantic proximity Read ↗

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferationSemantic proximity Read ↗

Unveiling the Tumor Suppressors: Insights from Drosophila.Semantic proximity Read ↗

Tissue repair through cell competition and compensatory cellular hypertrophy in postmitotic epithelia.Semantic proximity Read ↗

Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition.Semantic proximity Read ↗

Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient RestrictionSemantic proximity Read ↗

Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.Semantic proximity Read ↗

Starvation resistance in planarians: multiple strategies to get a thrifty phenotype.Semantic proximity Read ↗

A chloroquine sensitivity gradient induces tissue regeneration and maintenance phenotypes in planarians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.