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Article

The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.

The Journal of biological chemistry - 5 Sept 2014

Backus Keriann M, Dolan Michael A, Barry Conor S, Joe Maju, McPhie Peter, Boshoff Helena I M, Lowary Todd L, Davis Benjamin G, Barry Clifton E

Abstract excerpt

The three isoforms of antigen 85 (A, B, and C) are the most abundant secreted mycobacterial proteins and catalyze transesterification reactions that synthesize mycolated arabinogalactan, trehalose monomycolate (TMM), and trehalose dimycolate (TDM), important constituents of the outermost layer of the cellular envelope of Mycobacterium tuberculosis. These three enzymes are nearly identical at the active site and...

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Identifiers

PMID: 25028517
DOI: 10.1074/jbc.M114.581579
PMCID: PMC4155671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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