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Article

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.

ACS chemical biology - 20 Jan 2017

Jankute Monika, Alderwick Luke J, Noack Stephan, Veerapen Natacha, Nigou Jérôme, Besra Gurdyal S

Abstract excerpt

Lipoarabinomannan (LAM) and arabinogalactan (AG) are the two major mycobacterial cell wall (lipo)polysaccharides, which contain a structurally similar arabinan domain that is highly branched and assembled in a stepwise fashion by variety of arabinofuranosyltransferases (ArafT). In addition to playing an essential role in mycobacterial physiology, LAM and its biochemical precursor lipomannan possess potent...

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Identifiers

PMID: 28033704
DOI: 10.1021/acschembio.6b00898
PMCID: PMC5259755

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