Article
Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials.
The international journal of neuropsychopharmacology - 3 Dec 2020
Saad Ziad, Hibar Derrek, Fedgchin Maggie, Popova Vanina, Furey Maura L, Singh Jaskaran B, Kolb Hartmuth, Drevets Wayne C, Chen Guang
Abstract excerpt
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has shown mu-opioid receptor (MOR-gene symbol: OPRM1) agonist effects. Preliminary clinical studies showed conflicting results on whether naltrexone, a MOR antagonist, blocks the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.