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Article

Opioid receptor polymorphism A118G associated with clinical severity in a drug overdose population.

Journal of medical toxicology : official journal of the American College of Medical Toxicology - 1 Jun 2013

Manini A F, Jacobs M M, Vlahov D, Hurd Y L

Abstract excerpt

Genetic variations in the human mu-opioid receptor gene (OPRM1) mediate individual differences in response to pain and opiate addiction. We studied whether the common A118G (rs1799971) mu-opioid receptor single nucleotide polymorphism (SNP) was associated with overdose severity in humans. In addition, we examined an SNP responsible for alternative splicing of OPRM1 (rs2075572). We assessed allele frequencies of...

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Identifiers

PMID: 23318993
DOI: 10.1007/s13181-012-0286-3
PMCID: PMC3648633

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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