Article
RAPID COMMUNICATION: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system.
Journal of animal science - 1 May 2017
Hu R, Fan Z Y, Wang B Y, Deng S L, Zhang X S, Zhang J L, Han H B, Lian Z X
Abstract excerpt
Sheep are an important source of fiber production. Fibroblast growth factor 5 (FGF5) is a dominant inhibitor of length of the anagen phase of the hair cycle. Knockout or silencing of the gene results in a wooly coat in mice, donkeys, dogs, and rabbits. In sheep breeding, wool length is one of the most important wool quality traits. However, traditional breeding cannot accurately and efficiently mediate an...
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