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Article

Predictable CRISPR/Cas9-Mediated COL7A1 Reframing for Dystrophic Epidermolysis Bullosa.

The Journal of investigative dermatology - 1 Oct 2020

Kocher Thomas, March Oliver Patrick, Bischof Johannes, Liemberger Bernadette, Hainzl Stefan, Klausegger Alfred, Hoog Anna, Strunk Dirk, Bauer Johann Wolfgang, Koller Ulrich

Abstract excerpt

End-joining‒based gene editing is frequently used for efficient reframing and knockout of target genes. However, the associated random, unpredictable, and often heterogeneous repair outcomes limit its applicability for therapeutic approaches. This study revealed more precise and predictable outcomes simply on the basis of the sequence context at the CRISPR/Cas9 target site. The severe dystrophic form of the...

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Share to Collagen Type VII
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Source

Identifiers

PMID: 32142798
DOI: 10.1016/j.jid.2020.02.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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