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Article

Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations.

Scientific reports - 30 Apr 2020

Pierini Federica, Nutsua Marcel, Böhme Lisa, Özer Onur, Bonczarowska Joanna, Susat Julian, Franke Andre, Nebel Almut, Krause-Kyora Ben, Lenz Tobias L

Abstract excerpt

The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for targeted analysis of polymorphic loci from low-coverage shotgun sequence data. The pipeline was...

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Identifiers

PMID: 32355290
DOI: 10.1038/s41598-020-64312-w
PMCID: PMC7193575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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