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Article

Comparison of gene disruption induced by cytosine base editing-mediated iSTOP with CRISPR/Cas9-mediated frameshift.

Cell proliferation - 1 May 2020

Dang Lu, Li Guanglei, Wang Xinjie, Huang Shisheng, Zhang Yu, Miao Yuanxin, Zeng Lisi, Cui Shuzhong, Huang Xingxu

Abstract excerpt

OBJECTIVES: Recently developed CRISPR-dependent cytosine base editor (CBE), converting four codons (CAA, CAG, CGA and TGG) into stop codons without DNA double-strand breaks (DSB), serves as an efficient gene disruption strategy besides uncontrollable CRISPR-mediated frameshift. However, the detailed difference of gene knockout between the two systems has not been clarified. MATERIALS AND METHODS: Here, we...

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Identifiers

PMID: 32350961
DOI: 10.1111/cpr.12820
PMCID: PMC7260061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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