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Article

Phenotypes of Aging Postovulatory Oocytes After Somatic Cell Nuclear Transfer in Mice.

Cellular reprogramming - 1 Jun 2016

Lee Ah Reum, Shimoike Takashi, Wakayama Teruhiko, Kishigami Satoshi

Abstract excerpt

Oocytes rapidly lose their developmental potential after ovulation, termed postovulatory oocyte aging, and often exhibit characteristic phenotypes, such as cytofragmentation, abnormal spindle shapes, and chromosome misalignments. Here, we reconstructed mouse oocytes using somatic cell nuclear transfer (SCNT) to reveal the effect of somatic cell-derived nuclei on oocyte physiology during aging. Normal oocytes...

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Identifiers

PMID: 27253626
DOI: 10.1089/cell.2016.0014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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