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Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

30 Apr 2020

Abstract excerpt

STUDY QUESTION: Can pronuclear transfer (PNT) or maternal spindle transfer (ST) be applied to overcome poor embryo development associated with advanced maternal age or early embryo arrest in a mouse model? SUMMARY ANSWER: Both PNT and ST may have the potential to restore embryonic developmental potential in a mouse model of reproductive ageing and embryonic developmental arrest. WHAT IS KNOWN ALREADY: Germline...

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PMID: 32613230
DOI: 10.1093/humrep/deaa112

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