Article
Genome transfer for the prevention of female infertility caused by maternal gene mutation.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jun 2020
Bai Dandan, Sun Jin, Jia Yanping, Yin Jiqing, Zhang Yalin, Li Yanhe, Gao Rui, Du Xiling, Li Kunming, Lin Jiaming, Tu Zhifen, Wang Yu, Pan Jiaping, Liang Shanshan, Guo Yi, Ruan Jingling, Kou Xiaochen, Zhao Yanhong, Wang Hong, Jiang Cizhong, Wang Fengchao, Teng Xiaoming, Liu Wenqiang, Gao Shaorong
Abstract excerpt
Poor oocyte quality is associated with early embryo developmental arrest and infertility. Maternal gene plays crucial roles in the regulation of oocyte maturation, and its mutation is a common cause of female infertility. However, how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive. Here, we use Zar1 as an example to assess the feasibility of genome transfer to...
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