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Article

Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease.

Scientific reports - 28 Apr 2020

Blumenau Sonja, Foddis Marco, Müller Susanne, Holtgrewe Manuel, Bentele Kajetan, Berchtold Daniel, Beule Dieter, Dirnagl Ulrich, Sassi Celeste

Abstract excerpt

Alzheimer's disease and small vessel ischemic disease frequently co-exist in the aging brain. However, pathogenic links between these 2 disorders are yet to be identified. Therefore we used Taqman genotyping, exome and RNA sequencing to investigate Alzheimer's disease known pathogenic variants and pathways: APOE ε4 allele, APP-Aβ metabolism and late-onset Alzheimer's disease main genome-wide association loci...

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Identifiers

PMID: 32345996
DOI: 10.1038/s41598-020-63183-5
PMCID: PMC7188838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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