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Article

Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease.

Brain : a journal of neurology - 1 Nov 2011

Schmidt Helena, Zeginigg Marion, Wiltgen Marco, Freudenberger Paul, Petrovic Katja, Cavalieri Margherita, Gider Pierre, Enzinger Christian, Fornage Myriam, Debette Stephanie, Rotter Jerome I, Ikram Mohammad A, Launer Lenore J, Schmidt Reinhold

Abstract excerpt

Cerebral small vessel disease-related brain lesions such as white matter lesions and lacunes are common findings of magnetic resonance imaging in the elderly. These lesions are thought to be major contributors to disability in old age, and risk factors that include age and hypertension have been established. The radiological, histopathologic and clinical phenotypes of age-related cerebral small vessel disease...

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Identifiers

PMID: 22006983
DOI: 10.1093/brain/awr252
PMCID: PMC3212720

Genes

NOTCH3

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