Article
Investigating a Genetic Link Between Alzheimer's Disease and CADASIL-Related Cerebral Small Vessel Disease.
Molecular neurobiology - 1 Dec 2022
Dunn Paul J, Lea Rodney A, Maksemous Neven, Smith Robert A, Sutherland Heidi G, Haupt Larisa M, Griffiths Lyn R
Abstract excerpt
Monogenic forms of Alzheimer's disease (AD) have been identified through mutations in genes such as APP, PSEN1, and PSEN2, whilst other genetic markers such as the APOE ε carrier allele status have been shown to increase the likelihood of having the disease. Mutations in these genes are not limited to AD, as APP mutations can also cause an amyloid form of cerebral small vessel disease (CSVD) known as cerebral...
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