Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome.

Translational psychiatry - 28 Apr 2020

Courtois Elisa, Schmid Mark, Wajsbrot Orly, Barau Caroline, Le Corvoisier Philippe, Aouizerate Bruno, Bellivier Frank, Belzeaux Raoul, Dubertret Caroline, Kahn Jean-Pierre, Leboyer Marion, Olie Emilie, Passerieux Christine, Polosan Mircea, Etain Bruno, Jamain Stéphane

Abstract excerpt

Genome-wide association studies on bipolar disorders (BD) have revealed an additive polygenic contribution of common single-nucleotide polymorphisms (SNPs). However, these SNPs explain only 25% of the overall genetic variance and suggest a role of rare variants in BD vulnerability. Here, we combined high-throughput genotyping data and whole-exome sequencing in cohorts of individuals with BD as well as in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 32345981
DOI: 10.1038/s41398-020-0783-0
PMCID: PMC7188882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome.PMID 32345981Read ↗

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.Semantic proximity Read ↗

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disordersSemantic proximity Read ↗

Rare deleterious mutations are associated with disease in bipolar disorder families.Semantic proximity Read ↗

Exome Sequencing of Familial Bipolar Disorder.Semantic proximity Read ↗

Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants.Semantic proximity Read ↗

Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.Semantic proximity Read ↗

Polygenic Risk Scores for Bipolar Disorder: Progress and PerspectivesSemantic proximity Read ↗

Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families.Semantic proximity Read ↗

New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.Semantic proximity Read ↗

Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder.Semantic proximity Read ↗

Psychiatric Polygenic Risk Scores Across Youth With Bipolar Disorder, Youth at High Risk for Bipolar Disorder, and Controls.Semantic proximity Read ↗

An examination of multiple classes of rare variants in extended families with bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.