Article
Exome Sequencing of Familial Bipolar Disorder.
JAMA psychiatry - 1 Jun 2016
Goes Fernando S, Pirooznia Mehdi, Parla Jennifer S, Kramer Melissa, Ghiban Elena, Mavruk Senem, Chen Yun-Ching, Monson Eric T, Willour Virginia L, Karchin Rachel, Flickinger Matthew, Locke Adam E, Levy Shawn E, Scott Laura J, Boehnke Michael, Stahl Eli, Moran Jennifer L, Hultman Christina M, Landén Mikael, Purcell Shaun M, Sklar Pamela, Zandi Peter P, McCombie W Richard, Potash James B
Abstract excerpt
IMPORTANCE: Complex disorders, such as bipolar disorder (BD), likely result from the influence of both common and rare susceptibility alleles. While common variation has been widely studied, rare variant discovery has only recently become feasible with next-generation sequencing. OBJECTIVE: To utilize a combined family-based and case-control approach to exome sequencing in BD using multiplex families as an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.