Article
Rare deleterious mutations are associated with disease in bipolar disorder families.
Molecular psychiatry - 1 Jul 2017
Rao A R, Yourshaw M, Christensen B, Nelson S F, Kerner B
Abstract excerpt
Bipolar disorder (BD) is a common, complex and heritable psychiatric disorder characterized by episodes of severe mood swings. The identification of rare, damaging genomic mutations in families with BD could inform about disease mechanisms and lead to new therapeutic interventions. To determine whether rare, damaging mutations shared identity-by-descent in families with BD could be associated with disease, exome...
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