Article
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Molecular psychiatry - 1 Apr 2021
Andlauer Till F M, Guzman-Parra Jose, Streit Fabian, Strohmaier Jana, González Maria José, Gil Flores Susana, Cabaleiro Fabeiro Francisco J, Del Río Noriega Francisco, Perez Fermin Perez, Haro González Jesus, Orozco Diaz Guillermo, de Diego-Otero Yolanda, Moreno-Küstner Berta, Auburger Georg, Degenhardt Franziska, Heilmann-Heimbach Stefanie, Herms Stefan, Hoffmann Per, Frank Josef, Foo Jerome C, Treutlein Jens, Witt Stephanie H, Cichon Sven, Kogevinas Manolis, Rivas Fabio, Mayoral Fermín, Müller-Myhsok Bertram, Forstner Andreas J, Nöthen Markus M, Rietschel Marcella
Abstract excerpt
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated...
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