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Chronic myelomonocytic leukemia with double activating <i>KRAS</i> mutations: molecular characterization of an uncommon case

2026-01-23

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a clonal myelodysplastic/myeloproliferative neoplasm characterized by persistent monocytosis and heterogeneous risk of progression to acute leukemia. Mutations within the RAS/MAPK signaling pathway, particularly involving KRAS, are linked to a proliferative disease phenotype and adverse prognosis. We report the first Colombian CMML case harboring two concurrent activating...

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Literature Corpus work
4da156a1-4ba9-53d0-b8ab-34c39848c443
DOI
10.64898/2026.01.21.26344030
Open publication

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