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Article

RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2010

Ricci Clara, Fermo Elisa, Corti Stefania, Molteni Mauro, Faricciotti Alessio, Cortelezzi Agostino, Lambertenghi Deliliers Giorgio, Beran Miloslav, Onida Francesco

Abstract excerpt

PURPOSE: The biological and clinical heterogeneity of chronic myelomonocytic leukemia features renders its classification difficult. Moreover, because of the limited knowledge of the mechanisms involved in malignant evolution, chronic myelomonocytic leukemia remains a diagnostic and therapeutic challenge and a poor prognosis disease. We aimed to verify the biological and clinical significance of the...

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Source

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PMID: 20371679
DOI: 10.1158/1078-0432.CCR-09-2112

Genes

FLT3
JAK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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