Article
Molecular Basis and Clinical Application of Growth-Factor-Independent In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia.
International journal of molecular sciences - 22 Aug 2020
Geissler Klaus, Jäger Eva, Barna Agnes, Gurbisz Michael, Graf Temeida, Graf Elmir, Nösslinger Thomas, Pfeilstöcker Michael, Machherndl-Spandl Sigrid, Stauder Reinhard, Zebisch Armin, Sill Heinz, Öhler Leopold, Kusec Rajko, Hörmann Gregor, Valent Peter
Abstract excerpt
We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia (CMML) and a strong predictor for short survival. Elucidation of the molecular basis underlying this in vitro phenomenon could be helpful to define molecular features that predict inferior outcome in patients. We studied the correlation between the mutational...
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