Article
Phenotypic subtypes of leukaemic transformation in chronic myelomonocytic leukaemia.
British journal of haematology - 1 Nov 2023
Montalban-Bravo Guillermo, Kanagal-Shamanna Rashmi, Li Ziyi, Hammond Danielle, Chien Kelly, Rodriguez-Sevilla Juan Jose, Sasaki Koji, Jabbour Elias, DiNardo Courtney, Takahashi Koichi, Short Nicholas, Issa Ghayas C, Pemmaraju Naveen, Kadia Tapan, Ravandi Farhad, Daver Naval, Borthakur Gautam, Loghavi Sanam, Pierce Sherry, Bueso-Ramos Carlos, Kantarjian Hagop, Garcia-Manero Guillermo
Abstract excerpt
Chronic myelomonocytic leukaemia (CMML) is a haematological disorder with high risk of transformation to acute myeloid leukaemia (AML). To characterize the phenotypic and genomic patterns of CMML progression, we evaluated a cohort of 189 patients with AML evolving from CMML. We found that transformation occurs through distinct trajectories characterized by genomic profiles and clonal evolution: monocytic (Mo-AML,...
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