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Article

Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population

28 Apr 2020

Abstract excerpt

Epilepsy is clinically heterogeneous, and neurological or psychiatric comorbidities are frequently observed in patients. It has not been tested whether common risk variants for generalized or focal epilepsy are enriched in people with other disorders or traits related to brain or cognitive function. Here, we perform two brain-focused phenome association studies of polygenic risk scores (PRS) for generalized...

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PMID: 32343744
DOI: 10.1371/journal.pone.0232292

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